After a series of unsuccessful battles with Spider-Man, Norman Osborn, Dr. Octopus, Electro and the Sandman have been incarcerated together in a prison-wing of the S.H.I.E.L.D. Triskelion. Charged with illegally tampering with their genetic structure, Nick Fury claims that they're there at his pleasure, de-powered and with no hope of release. There is, however, hope of rehabilitation if they choose to co-operate with S.H.I.E.L.D.
Elsewhere in the city, Kraven the Hunter has returned. In a televised interview, he offers viewers the chance to see him hunt down Spider-Man and this time the outcome will be in his favor. But what of the rumors of a "new and improved" Kraven? Will this bring him to the attention of The Ultimates?
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